PG-11047
PG-11047 (CGC-11047) is a polyamine analogue. PG-11047 can be used for the research of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 308145-19-9
- Formula: C14H32N4
- Molecular Weight:256.43
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PG-11047 (13 nM-5 mM; 72 h) inhibit growth of members of the panel of breast cell lines varied over a wide range, with basal-like cell lines being inhibited at lower concentrations than the luminal cell lines[1].
PG-11047 (0.3, 10, 300 μM; 48 h, 72 h) shows a significant decrease in S phase fraction at doses that produced little apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast cancer cell lines
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Concentration:0.3, 10, 300 μM
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Incubation Time:48 h, 72 h
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Result:Significant decreased the fraction of cells in S-phase with increasing doses.
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Cell Line:Breast cancer cell lines
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Concentration:0.3, 10, 300 μM
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Incubation Time:48 h, 72 h
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Result:Induced apoptosis at high concentrations.
Chemical Information
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CAS No. 308145-19-9
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Appearance Oil
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Molecular Weight 256.43
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Formula C14H32N4
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Color Light yellow to yellow
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SMILES
CCNCCCNC/C=C\CNCCCNCC
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Synonyms
CGC-11047
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (389.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (9.75 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.75 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8997 mL | 19.4985 mL | 38.9970 mL | 97.4925 mL |
| 5 mM | 0.7799 mL | 3.8997 mL | 7.7994 mL | 19.4985 mL | |
| 10 mM | 0.3900 mL | 1.9498 mL | 3.8997 mL | 9.7492 mL | |
| 15 mM | 0.2600 mL | 1.2999 mL | 2.5998 mL | 6.4995 mL | |
| 20 mM | 0.1950 mL | 0.9749 mL | 1.9498 mL | 4.8746 mL | |
| 25 mM | 0.1560 mL | 0.7799 mL | 1.5599 mL | 3.8997 mL | |
| 30 mM | 0.1300 mL | 0.6499 mL | 1.2999 mL | 3.2497 mL | |
| 40 mM | 0.0975 mL | 0.4875 mL | 0.9749 mL | 2.4373 mL | |
| 50 mM | 0.0780 mL | 0.3900 mL | 0.7799 mL | 1.9498 mL | |
| 60 mM | 0.0650 mL | 0.3250 mL | 0.6499 mL | 1.6249 mL | |
| 80 mM | 0.0487 mL | 0.2437 mL | 0.4875 mL | 1.2187 mL | |
| 100 mM | 0.0390 mL | 0.1950 mL | 0.3900 mL | 0.9749 mL |
PG-11047 Related Classifications
HY-16395 Related Classifications
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