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Cat. No.: HY-169608

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BCR-ABL-IN-11

BCR-ABL-IN-11 (Compound 2) is a BCR-ABL inhibitor. BCR-ABL-IN-11 shows anticancer activity against chronic myelogenous leukemia (CML) (IC₅₀ of 129.61 μM for K562 cells).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2362-25-6
화학식: C₂₀H₁₈N₄O₂
분자량:346.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

BCR-ABL-IN-11 Chemical Structure

CAS No.: 2362-25-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

BCR-ABL-IN-11 (Compound 2) is a BCR-ABL inhibitor. BCR-ABL-IN-11 shows anticancer activity against chronic myelogenous leukemia (CML) (IC₅₀ of 129.61 μM for K562 cells)^[1].

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	129.61 μM Compound: 2	Inhibitory activity against human K562 cells growth using MTT assay Inhibitory activity against human K562 cells growth using MTT assay	[PMID: 14552760]

Chemical Information

CAS No. 2362-25-6
분자량 346.38
화학식 C₂₀H₁₈N₄O₂
SMILES

O=C(C1=CC=C(C=C1)N)NC2=CC=CC(NC(C3=CC=C(C=C3)N)=O)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Peng H, et al. Identification of novel inhibitors of BCR-ABL tyrosine kinase via virtual screening. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3693-9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BCR-ABL-IN-11

DPH

Lyn-IN-1

Vodobatinib

Asciminib hydrochloride

Olverembatinib dimesylate

Bosutinib hydrate

SIAIS178

ON 146040

Hydroxymethyl dasatinib

BCR-ABL-IN-7

Bosutinib hydrate (Standard)

Asciminib hydrochloride (Standard)

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

BCR-ABL-IN-11

DPH

Lyn-IN-1

Vodobatinib

Asciminib hydrochloride

Olverembatinib dimesylate

Bosutinib hydrate

SIAIS178

ON 146040

Hydroxymethyl dasatinib

BCR-ABL-IN-7

Bosutinib hydrate (Standard)

Asciminib hydrochloride (Standard)

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BCR-ABL-IN-11 Related Classifications

HY-169608 Related Classifications

Bioz