1. Apoptosis
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  3. Beta-Zearalanol

Beta-Zearalanol 

Cat. No.: HY-N6740
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Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid.

For research use only. We do not sell to patients.

Beta-Zearalanol Chemical Structure

Beta-Zearalanol Chemical Structure

CAS No. : 42422-68-4

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Description

Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells[1]. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid[2].

In Vitro

βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC50 of 25 μM[1].
βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC50 of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC50 values of 19.8 uM, 16.8 uM, respectively[2].
βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol[2].

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.

Cell Proliferation Assay[1]

Cell Line: BGC cells
Concentration: 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
Incubation Time: 24 hours
Result: Inhibited cell proliferation in a dose-dependent manner.

RT-PCR[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Had the higher cytotoxic effect in comparation with α-Zearalenol.
Molecular Weight

322.40

Formula

C₁₈H₂₆O₅

CAS No.

42422-68-4

SMILES

O=C1C2=C(O)C=C(O)C=C2CCCCC[[email protected]](O)CCC[[email protected]](C)O1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Beta-Zearalanol
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