Bethanidine

Bethanidine (BW 467C60 (free base)) is an orally active antihypertensive agent and adrenergic neuron blocking agent. Bethanidine exerts its antihypertensive effect by inhibiting the release of norepinephrine from sympathetic nerve terminals. Bethanidine prolongs the action potential duration and the effective/functional refractory period, slows the recovery of membrane excitability after repolarization, and suppresses spontaneous action potentials induced by paired stimulation when the refractory period is sufficiently prolonged. Bethanidine shortens the duration of ventricular tachyarrhythmias and prevents electrically induced ventricular tachycardia. Bethanidine reduces metabolic rate and improves energy utilization efficiency in mice, resulting in a significant increase in body fat. Bethanidine restores tyramine-induced cardiovascular effects in Reserpine (HY-N0480)-treated anesthetized rats depleted of catecholamines. Bethanidine can be used in research on arrhythmias, inflammatory bowel disease, and primary hypertension.

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