BI-8128
BI-8128 is a potent EGFR inhibitor, with IC50 values of 12, 6.7, 22, 10, and 3 nM against wild-type, T790M, C797S, T790M/C797S, and L858R/T790M/C797S mutant EGFR, respectively. BI-8128 significantly inhibits the proliferation of Ba/F3 and PC-9 drug-resistant mutant cells. BI-8128 is applicable for the research of non-small cell lung cancer.
For research use only. We do not sell to patients.
The BI-8128 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
- CAS No.: 2769714-36-3
- Formula: C32H38N10O3
- Molecular Weight:610.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
|
EGFR (WT) 12 nM (IC50) |
EGFRT790M 6.7 nM (IC50) |
EGFRC797S 22 nM (IC50) |
EGFRdel19 T790M C797S 10 nM (IC50) |
EGFRL858R/T790M/C797S 3 nM (IC50) |
BI-8128 potently inhibits the proliferation of Ba/F3 del19 EGFR cells (IC50 = 1.7 nM), and exhibits significant antiproliferative activity against other cell lines expressing EGFR mutants and wild-type (WT) EGFR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2769714-36-3
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Molecular Weight 610.71
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Formula C32H38N10O3
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SMILES
[H][C@@]12CN([C@@](CO1)(C2)[H])C3=C4N=C(N5CCN(CC5)CCOC)N(C4=CC(N6N=CC7=C(N=C(C8=C(C=CN=C8)OC)C=C67)C)=N3)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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