Bifenox (Synonyms: MC-4379)

Cat. No.: HY-136513 Purity: 99.77%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Bifenox (MC-4379) is a nitrophenyl ether herbicide. Bifenox disrupts cellular membrane, inhibits photosynthesis and inhibits the protoporphyrinogen oxidase. Bifenox increases the ROS production in the microalgae Chlamydomonas reinhardtii.

For research use only. We do not sell to patients.

Bifenox Chemical Structure

CAS No. : 42576-02-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Bifenox:

Bifenox-d₃ Get quote
Bifenox-d₃-1 Get quote

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Description

Molecular Weight

342.13

Formula

C₁₄H₉Cl₂NO₅

CAS No.

42576-02-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC)C1=CC(OC2=CC=C(Cl)C=C2Cl)=CC=C1[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (292.29 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9229 mL	14.6143 mL	29.2287 mL
5 mM	0.5846 mL	2.9229 mL	5.8457 mL
10 mM	0.2923 mL	1.4614 mL	2.9229 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (7.31 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (7.31 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (272 KB) SDS (459 KB)

COA (248 KB) HNMR (120 KB) RP-HPLC (231 KB)

Handling Instructions (2659 KB)

References

[1]. Almeida AC, et al. Oxidative stress potential of the herbicides bifenox and metribuzin in the microalgae Chlamydomonas reinhardtii. Aquat Toxicol. 2019 May;210:117-128. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9229 mL	14.6143 mL	29.2287 mL	73.0716 mL
	5 mM	0.5846 mL	2.9229 mL	5.8457 mL	14.6143 mL
	10 mM	0.2923 mL	1.4614 mL	2.9229 mL	7.3072 mL
	15 mM	0.1949 mL	0.9743 mL	1.9486 mL	4.8714 mL
	20 mM	0.1461 mL	0.7307 mL	1.4614 mL	3.6536 mL
	25 mM	0.1169 mL	0.5846 mL	1.1691 mL	2.9229 mL
	30 mM	0.0974 mL	0.4871 mL	0.9743 mL	2.4357 mL
	40 mM	0.0731 mL	0.3654 mL	0.7307 mL	1.8268 mL
	50 mM	0.0585 mL	0.2923 mL	0.5846 mL	1.4614 mL
	60 mM	0.0487 mL	0.2436 mL	0.4871 mL	1.2179 mL
	80 mM	0.0365 mL	0.1827 mL	0.3654 mL	0.9134 mL
	100 mM	0.0292 mL	0.1461 mL	0.2923 mL	0.7307 mL

Bifenox Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bifenox42576-02-3MC-4379MC4379MC 4379Reactive Oxygen Species (ROS)Environmental PollutantsProtoporphyrinogen IX oxidaseHerbicideEnvironmental Contaminantselectron transportROSChlamydomonas reinhardtiiherbicideChlorophyll a (Chl a)chlorophyll bInhibitorinhibitorinhibit

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Bifenox (Synonyms: MC-4379)

Other Forms of Bifenox:

Bifenox Related Antibodies

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