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Cat. No.: HY-107022A

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BMS-341400 mesylate

BMS-341400 mesylate is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC₅₀ value of 0.3 nM. BMS-341400 mesylate reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 mesylate can be used to study erectile dysfunction.

For research use only. We do not sell to patients.

CAS No.: 296250-54-9
Formula: C₂₄H₂₆ClN₉O₅S
Molecular Weight:588.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

BMS-341400 mesylate Chemical Structure

CAS No.: 296250-54-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PDE5

0.3 nM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

BMS-341400 (Compound 6) mesylate effectively enhanced the relaxation of the smooth muscle in the isolated tissue of the rabbit penile corpus cavernosum, with its EC₅₀ value being 13 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	T_1/2
Dog^[1]	5.1 μmol/Kg	p.o.	42 %	2 h
Rat^[1]	2 μmol/Kg	p.o.	29 %	1.2 h

In Vivo

BMS-341400 (Compound 6) (10-1000 nmol/kg, i.v., single dose) mesylate effectively promotes the erectile response in the male rabbit model with EC₅₀ value of 100 nmol/kg^[1].
BMS-341400 (10-250 mg/kg) mesylate demonstrates excellent safety in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Anesthesia-induced male rabbit model^[1]
Dosage:

10, 30, 100, 300, and 1000 nmol/kg
Administration:

Intravenous injection (i.v.), single dose
Result:

Had an equivalent efficacy in promoting erections in the body as Sildenafil (HY-15025).

Chemical Information

CAS No. 296250-54-9
Molecular Weight 588.04
Formula C₂₄H₂₆ClN₉O₅S
SMILES

CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1.CS(O)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yu G, et al. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2003 Feb 13;46(4):457-60. [Content Brief]

[2]. Pryor JL, Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. International journal of impotence research. 2000 Oct;12(4):S158-62.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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BMS-341400 mesylate

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BMS-341400 mesylate Related Classifications

HY-107022A Related Classifications