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Art. -Nr.: HY-107022

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BMS-341400

BMS-341400 is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC₅₀ value of 0.3 nM. BMS-341400 reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 can be used to study erectile dysfunction.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 296250-53-8
Formel: C₂₃H₂₂ClN₉O₂
Molecular Weight:491.93

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

BMS-341400 Chemical Structure

CAS. Nr.: 296250-53-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

PDE5

0.3 nM (IC₅₀)

Alle Phosphodiesterase (PDE) Isoform-spezifische Produkte anzeigen :

In Vitro

BMS-341400 (Compound 6) effectively enhanced the relaxation of the smooth muscle in the isolated tissue of the rabbit penile corpus cavernosum, with its EC₅₀ value being 13 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	F	T_1/2
Dog	5.1 μmol/Kg	p.o.	42 %	2 h
Rat	2 μmol/Kg	p.o.	29 %	1.2 h

In Vivo

BMS-341400 (Compound 6) (10-1000 nmol/kg, i.v., single dose) effectively promotes the erectile response in the male rabbit model with EC₅₀ value of 100 nmol/kg^[1].
BMS-341400 (10-250 mg/kg) demonstrates excellent safety in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Anesthesia-induced male rabbit model^[1]
Dosage:

10, 30, 100, 300, and 1000 nmol/kg
Administration:

Intravenous injection (i.v.), single dose
Result:

Had an equivalent efficacy in promoting erections in the body as Sildenafil (HY-15025).

Chemical Information

CAS. Nr. 296250-53-8
Molecular Weight 491.93
Formel C₂₃H₂₂ClN₉O₂
SMILES

CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yu G, et al. Substituted pyrazolopyridopyridazines as orally bioavailable potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2003 Feb 13;46(4):457-60. [Content Brief]

[2]. Pryor JL, Redmon B. New therapies and delivery mechanisms for treatment of erectile dysfunction. International journal of impotence research. 2000 Oct;12(4):S158-62.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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