2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. BRD2492

BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 exhibits >100-fold selectivity for HDAC1/2 over selectivity over HDAC3 and HDAC6. BRD2492 inhibits breast cancer cell lines growth with IC50s of 1.01 μM and 11.13 μM for T-47D and MCF-7 cells, respectively.

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BRD2492

BRD2492 화학구조

CAS No. : 1821669-43-5

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

BRD2492 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 exhibits >100-fold selectivity for HDAC1/2 over selectivity over HDAC3 and HDAC6. BRD2492 inhibits breast cancer cell lines growth with IC50s of 1.01 μM and 11.13 μM for T-47D and MCF-7 cells, respectively[1].

IC50 & Target[1]

HDAC1

13.2 nM (IC50)

HDAC2

77.2 nM (IC50)

HDAC3

8908 nM (IC50)

HDAC6

>1000 nM (IC50)

분자량

346.38

화학식

C20H18N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=C(N)C=CC(C2=CC=NC=C2)=C1)C3=CC=C(NC(C)=O)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 31.25 mg/mL (90.22 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8870 mL 14.4350 mL 28.8700 mL
5 mM 0.5774 mL 2.8870 mL 5.7740 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8870 mL 14.4350 mL 28.8700 mL 72.1751 mL
5 mM 0.5774 mL 2.8870 mL 5.7740 mL 14.4350 mL
10 mM 0.2887 mL 1.4435 mL 2.8870 mL 7.2175 mL
15 mM 0.1925 mL 0.9623 mL 1.9247 mL 4.8117 mL
20 mM 0.1444 mL 0.7218 mL 1.4435 mL 3.6088 mL
25 mM 0.1155 mL 0.5774 mL 1.1548 mL 2.8870 mL
30 mM 0.0962 mL 0.4812 mL 0.9623 mL 2.4058 mL
40 mM 0.0722 mL 0.3609 mL 0.7218 mL 1.8044 mL
50 mM 0.0577 mL 0.2887 mL 0.5774 mL 1.4435 mL
60 mM 0.0481 mL 0.2406 mL 0.4812 mL 1.2029 mL
80 mM 0.0361 mL 0.1804 mL 0.3609 mL 0.9022 mL
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BRD2492 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD24921821669-43-5BRD 2492BRD-2492HDACHistone deacetylasesHDAC1/2 inhibitoranticancer effectInhibitorinhibitorinhibit

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상품명:
BRD2492
Cat. No.:
HY-124053
수량:
MCE Japan Authorized Agent:

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