country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-190484

Copy Link Print Information

BuChE-IN-24

BuChE-IN-24 is a selective, covalent BuChE inhibitor with a K_c of 1.338 µM. BuChE-IN-24 is also a prodrug of the 5-HT₄ receptor partial agonist 5-HT4R agonist-4 (HY-190485). BuChE-IN-24 partially reverses Scopolamine (HY-N0296)-induced working memory deficits in mice without altering locomotor activity or anxiety-like behavior. BuChE-IN-24 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₃₃H₃₇N₃O₆
Molecular Weight:571.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BuChE-IN-24 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

BuChE

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

BuChE-IN-24 (Compound 2h) acts as a covalent BuChE inhibitor with K_c 1.338 µM and k₃ 0.529 min^-1, while AChE kinetics were insufficient for reliable K_c/k₃ determination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_inf
Mice^[1]	0.3 mg/kg	i.n.	12.3 (brain) min·ng/mL
Mice^[1]	3 mg/kg	p.o.	35.1 (brain) min·ng/mL

In Vivo

BuChE-IN-24 (0.3 mg/kg; intranasal administration) partially reverses Scopolamine (HY-N0296)-induced working memory deficits in mice^[1].
BuChE-IN-24 (0.3 mg/kg; intranasal administration) increases cAMP in the hippocampus and prefrontal cortex of mice, which is consistent with central release of 5-HT₄ receptor agonists^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male and female; data pooled because no sex differences were observed)^[1]
Dosage:

0.3 mg/kg
Administration:

intranasal; liposome-in-thermosensitive mucoadhesive gel formulation
Result:

Scopolamine decreased the percentage of spontaneous alternation relative to control.
Partially reversed the scopolamine-induced working-memory deficit; all groups showed spontaneous alternation above the 50% chance level.

Related Protocols :

Chemical Information

Molecular Weight 571.66
Formula C₃₃H₃₇N₃O₆
SMILES

O=C(OC1=CC=CC(CN2CCC(COC3=NOC4=CC=CC(O[C@H]5COCC5)=C34)CC2)=C1)N(CC6=CC=CC=C6)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang A, et al. Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity[J]. European Journal of Medicinal Chemistry, 2026: 119383.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote