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Art. -Nr.: HY-190484

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BuChE-IN-24

BuChE-IN-24 is a selective, covalent BuChE inhibitor with a K_c of 1.338 µM. BuChE-IN-24 is also a prodrug of the 5-HT₄ receptor partial agonist 5-HT4R agonist-4 (HY-190485). BuChE-IN-24 partially reverses Scopolamine (HY-N0296)-induced working memory deficits in mice without altering locomotor activity or anxiety-like behavior. BuChE-IN-24 can be used for research on Alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₃H₃₇N₃O₆
Molecular Weight:571.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (285 KB)

BuChE-IN-24 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

BuChE

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

In Vitro

BuChE-IN-24 (Compound 2h) acts as a covalent BuChE inhibitor with K_c 1.338 µM and k₃ 0.529 min^-1, while AChE kinetics were insufficient for reliable K_c/k₃ determination^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_inf
Mice^[1]	0.3 mg/kg	i.n.	12.3 (brain) min·ng/mL
Mice^[1]	3 mg/kg	p.o.	35.1 (brain) min·ng/mL

In Vivo

BuChE-IN-24 (0.3 mg/kg; intranasal administration) partially reverses Scopolamine (HY-N0296)-induced working memory deficits in mice^[1].
BuChE-IN-24 (0.3 mg/kg; intranasal administration) increases cAMP in the hippocampus and prefrontal cortex of mice, which is consistent with central release of 5-HT₄ receptor agonists^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male and female; data pooled because no sex differences were observed)^[1]
Dosage:

0.3 mg/kg
Administration:

intranasal; liposome-in-thermosensitive mucoadhesive gel formulation
Result:

Scopolamine decreased the percentage of spontaneous alternation relative to control.
Partially reversed the scopolamine-induced working-memory deficit; all groups showed spontaneous alternation above the 50% chance level.

Related Protocols :

Chemical Information

Molecular Weight 571.66
Formel C₃₃H₃₇N₃O₆
SMILES

O=C(OC1=CC=CC(CN2CCC(COC3=NOC4=CC=CC(O[C@H]5COCC5)=C34)CC2)=C1)N(CC6=CC=CC=C6)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang A, et al. Design, synthesis and biological evaluation of pleiotropic prodrugs activated by cholinesterases and releasing a 5-HT4R agonist, with in vivo antiamnesic activity[J]. European Journal of Medicinal Chemistry, 2026: 119383.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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