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Cat. No.: HY-190473

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C6-I RocA

C6-I RocA is a Flavagline derivative. C6-I RocA is cytotoxic to multiple cancer cell lines. C6-I RocA inhibits EV-A71, accompanied by significant host cell cytotoxicity. C6-I RocA inhibits the growth of fungi such as Aspergillus and Candida. C6-I RocA can be used in research related to cancer, viral infections, and fungal infections.

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화학식: C₂₈H₂₈INO₆
분자량:601.43

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (315 KB)

C6-I RocA Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa S3	IC50	0.96 nM	Cytotoxicity against human HeLa S3 cells assessed as viability reduction incubated 72 hrs by MTT assay. Cytotoxicity against human HeLa S3 cells assessed as viability reduction incubated 72 hrs by MTT assay.	42854388
MCF7	IC50	0.75 nM	Cytotoxicity against human MCF-7 cells assessed as viability reduction incubated 72 hrs by MTT assay. Cytotoxicity against human MCF-7 cells assessed as viability reduction incubated 72 hrs by MTT assay.	42854388
KB	IC50	0.56 nM	Cytotoxicity against human KB cells assessed as viability reduction incubated 72 hrs by MTT assay. Cytotoxicity against human KB cells assessed as viability reduction incubated 72 hrs by MTT assay.	42854388
HT-29	IC50	0.83 nM	Cytotoxicity against human HT-29 cells assessed as viability reduction incubated 72 hrs by MTT assay. Cytotoxicity against human HT-29 cells assessed as viability reduction incubated 72 hrs by MTT assay.	42854388
HepG2	IC50	1.07 nM	Cytotoxicity against human Hep G2 cells assessed as viability reduction incubated 72 hrs by MTT assay. Cytotoxicity against human Hep G2 cells assessed as viability reduction incubated 72 hrs by MTT assay.	42854388

In Vitro

Anti-cancerFungal InfectionViral InfectionOthers

Anti-cancer

C6-I RocA (compound 6E) inhibits the viability of HeLa S3, MCF-7, KB, HT-29, and Hep G2 cells with IC₅₀ values of 0.96, 0.75, 0.56, 0.83, and 1.07 nM, respectively^[1].

Fungal Infection

C6-I RocA inhibits the growth of Aspergillus flavus, Aspergillus fumigatus, Candida albicans, Candida auris, and Candida parapsilosis, with MIC values of 4, 8, 4, 2, and 4 μg/mL, respectively^[1].

Viral Infection

C6-I RocA (10 nM) inhibits EV-A71 by ≥ 99.0% in RD cells, but it also causes significant RD host cell cytotoxicity^[1].

Others

C6-I RocA (molecular docking) is speculated to exert its mechanism of action through enhancing the clamping interaction of DEAD-box helicase (eIF4A) with RNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

분자량 601.43
화학식 C₂₈H₂₈INO₆
SMILES

O[C@@H]1[C@H](C(N(C)C)=O)[C@@H](C2=CC=CC=C2)[C@]3(C4=CC=C(OC)C=C4)OC5=CC(I)=CC(OC)=C5[C@@]31O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (315 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vrubliauskas D, et al. Flavaglines as cross-kingdom translation inhibitors: Heavy halides at C6 potentiate antineoplastic, antiviral, and antifungal activities. European journal of medicinal chemistry. 2026 Oct 07;321(Pt 1):119394.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Cat. No.:
수량:
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C6-I RocA