CBLC100
Based on 1 Customer Validation
CBLC100 is an anticancer compound that targets FACT, while inhibiting NF-κB and activating p53. CBLC100 induces cytotoxicity through p53-dependent apoptotic and non-apoptotic pathways. CBLC100 is applicable to the research of cancers such as fibrosarcoma.
For research use only. We do not sell to patients.
- CAS No.: 1197996-83-0
- Formula: C24H26N2O2
- Molecular Weight:374.48
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
In Vitro
CBLC100 potently activates p53 and inhibits NF-κB in cell-based reporter gene assays, with corresponding EC50 values of 0.03 μM and 0.06 μM[1].
CBLC100 exerts selective cytotoxicity against human fibrosarcoma HT1080 cells, while showing low toxicity toward normal human Wi38 diploid fibroblasts[1].
CBLC100 (0.2 μM; 1 h) traps the FACT complex on the chromatin of human fibrosarcoma HT1080 cells, while depleting soluble FACT subunits in the nucleoplasm[1].
CBLC100 enhances CK2-mediated phosphorylation of the C-terminal region of p53 in human fibrosarcoma HT1080 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1197996-83-0
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Appearance Solid
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Molecular Weight 374.48
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Formula C24H26N2O2
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Color Off-white to light brown
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SMILES
O=C1CCC2=C1C=CC3=C2C4=C(C=CC5=C4CCC5=O)N3CCN(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBLC100 Related Classifications
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