CGP 4832

The MIC of CGP-4832 (24 h) against Escherichia coli MG1655 in iron-limited RPMI-1640 (0.25 mg/L) is 32-fold lower than that in iron-rich MHII (8 mg/L)^[1].
CGP-4832 (24 h) does not show enhanced activity against Acinetobacter baumannii HUMC1 or LAC-4 in iron-limited RPMI-1640 compared with MHII, with MICs of 8 mg/L and 2 mg/L in RPMI-1640, respectively^[1].
CGP 4832 (hydroquinone form; 10 min) inhibits DNA-dependent RNA polymerase from Escherichia coli ETH 2018 with ED₅₀ values of 0.09 µg/mL and 0.06 µg/mL for crude and highly purified enzyme, respectively, and no correlation exists between MIC and enzyme inhibition among the bacterial strains tested^[2].
CGP 4832 exhibits activity against Gram-positive bacteria comparable to that of Rifampicin (HY-B0272), but is 80-400 times more potent against certain Gram-negative bacterial species, such as Escherichia coli ETH 2018 (MIC 0.01 µg/mL) and Salmonella AX 5 (MIC 0.5 µg/mL)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.