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(E,E)-GLL398

(E,E)-GLL398 is a selective estrogen receptor degrader with potent binding activity to ERα (IC50 = 1.14 nM). (E,E)-GLL398 can effectively degrade ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). The introduced boronic acid group of (E,E)-GLL398 gives it superior oral bioavailability, with an AUC of 36.9 μg·h/mL in rats, which is significantly higher than that of GW7604.

For research use only. We do not sell to patients.

  • CAS No.: 2077980-83-5
  • Formula: C25H23BO4
  • Molecular Weight:398.26
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • (E,E)-GLL398 Chemical Structure
    (E,E)-GLL398 Chemical Structure
CAS No.: 2077980-83-5
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609-228-6898
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Use of MCE Products

All Estrogen Receptor/ERR Isoforms

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  • (E,E)-GLL398 Chemical Structure
    (E,E)-GLL398 Chemical Structure
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  • (E,E)-GLL398