IL13RA2 - interleukin 13 receptor subunit alpha 2 Gene

Also Known as CT19; IL-13R; IL13BP; CD213A2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3598

About IL13RA2

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:115,003,982-115,017,616 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 23 paralogues. Biased expression in testis (RPKM 16.6), appendix (RPKM 2.7) and 6 other tissues.

Summary

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

IL13RA2 Products (1)

mRNA	Protein	Name
NM_000640.3	NP_000631.1	interleukin-13 receptor subunit alpha-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20223216	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL13RA2 Protein Structure

IL6Ra-bind

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
interleukin-13 receptor subunit alpha-2	IL-13 receptor subunit alpha-2

IL13RA2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL13RA2	Q14627	LGALS3	Homo sapiens	P17931	Anti Bait CoIP	29427412
Intra	IL13RA2	Q14627	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	IL13RA2	Q14627	IL13	Homo sapiens	P35225	Anti Bait CoIP	27629921
Intra	IL13RA2	Q14627	IL13	Homo sapiens	P35225	Anti Bait CoIP	23972995
Intra	IL13RA2	Q14627	TMEM219	Homo sapiens	Q86XT9	Anti Bait CoIP	27629921
Intra	IL13RA2	Q14627	TMEM219	Homo sapiens	Q86XT9	Y2H	27629921
Intra	IL13RA2	Q14627	TMEM219	Homo sapiens	Q86XT9	Anti Bait CoIP	29427412
Intra	IL13RA2	Q14627	TMEM219	Homo sapiens	Q86XT9	BiFC	27629921
Intra	IL13RA2	Q14627	CHI3L1	Homo sapiens	P36222	Anti Tag CoIP	23972995

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL13RA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75827	IL-13R alpha 2 Protein, Human (HEK293, His)	Q14627/NP_000631.1 (D27-L342)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75829	IL-13R alpha 2 Protein, Human (Biotinylated, HEK293, His)	Q14627/NP_000631.1 (D27-L342)	≥ 95%, as determined by reducing SDS-PAGE.

IL13RA2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811097	CD213a2 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P89707	IL-13Rα2 Antibody (YA9051)	WB, IP	human

Related Diseases

Diseases	Alias
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Granulomatous Disease, Chronic, Autosomal Recessive, 2	Chronic Granulomatous Disease Due To Deficiency Of Ncf-2 CGD2 Ncf2 Deficiency P67-Phox Deficiency Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii Granulomatous Disease, Chronic, Due To Ncf2 Deficiency Neutrophil Cytosol Factor 2 Deficiency Chronic Granulomatous Disease 2, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 2 Cdg2 Deficiency Of Ncf2 Deficiency Of P67-Phox Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii Deficiency Of Neutrophil Cytosol Factor 2 Avellino Corneal Dystrophy
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1848	Pep-1 (uncapped)		99.89%	Unkown
HY-P11287A	DOTA-Pep-1L TFA	Ligand	98.60%	Unkown
HY-P10292	NOTA-Pep-1L		98.60%	Unkown
HY-P11287	DOTA-Pep-1L	Ligand	/	Unkown
HY-RS06689	IL13RA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174637	Human IL13RA2 mRNA		/	Unkown
HY-RS18438	Il13ra2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24920	Il13ra2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IL13RA2	VGNC	VGNC:73709
Bos taurus	IL13RA2	VGNC	VGNC:30115
Mus musculus	IL13RA2	MGD	MGI:1277954
Rattus norvegicus	IL13RA2	RGD	RGD:620838
Canis familiaris	IL13RA2	VGNC	VGNC:41938
Felis catus	IL13RA2	VGNC	VGNC:67759
Others	IL13RA2	NCBI