ICT12035

ICT12035 (AZ2158) (1 µM) blocked fMLF-induced calcium mobilization in PC-3, SH-SY-5Y, and HCT-116 cancer cells^[1].
ICT12035 (100 µM; 96 h) showed no cytotoxicity against U87-MG cells, with cell viability above 95% at 100 µM^[1].
ICT12035 (1 µM; 5 days) eliminated the fMLF-induced increase in U87-MG cell proliferation in 2D culture^[1].
ICT12035 (1 µM; treated once every 24 h; monitored at 146 h, 172 h, and 197 h for up to 9 days) delayed the fMLF-induced increase in U87-MG multicellular spheroid growth^[1].
ICT12035 (2-20 µM; analyzed at 18 h and 39 h) eliminated the fMLF-induced increase in invasion of U87-MG multicellular spheroids^[1].
ICT12035 (10 nM-100 µM; 16 h) reduced the fMLF-induced increase in U87-MG cell invasion in a dose-dependent manner^[1].
ICT12035 (30 min) is a potent antagonist of FPR1 in U87-MG cells, with an IC₅₀ of 30 nM^[1] in calcium mobilization assays.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.