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Cat. No.: HY-125458

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Iromycin A

Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp..

For research use only. We do not sell to patients.

CAS No.: 213137-53-2
Formula: C₁₉H₂₉NO₂
Molecular Weight:303.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Iromycin A Chemical Structure

CAS No.: 213137-53-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp.^[1].

All NO Synthase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>30 μM Compound: 7, iromycin A	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 18054490]
L929	IC₅₀	66 μM Compound: 7, iromycin A	Cytotoxicity against mouse L929 fibroblasts Cytotoxicity against mouse L929 fibroblasts	[PMID: 18054490]
MCF7	IC₅₀	>30 μM Compound: 7, iromycin A	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 18054490]

Chemical Information

CAS No. 213137-53-2
Molecular Weight 303.44
Formula C₁₉H₂₉NO₂
SMILES

O=C1C(C)=C(O)C(CCC)=C(C/C=C(C)/C/C=C/C(C)C)N1
Structure Classification
- Others
Initial Source
- Microorganisms
Streptomyces sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Frank Surup, et al. The iromycins, a new family of pyridone metabolites from Streptomyces sp. I. Structure, NOS inhibitory activity, and biosynthesis. J Org Chem. 2007 Jul 6;72(14):5085-90. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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References

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Iromycin A

All NO Synthase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Iromycin A Related Classifications

HY-125458 Related Classifications