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MDX-1105

(Synonyms: BMS-936559)
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Based on 1 Customer Validation

MDX-1105 is a human antibody expressed in CHO that targets B7-H1/PD-L1/CD274. MDX-1105 has a huIgG4SP type heavy chain, and its predicted molecular weight (MW) is 150 kDa. The isotype control for MDX-1105 can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

For research use only. We do not sell to patients.

  • Purity : ≥99.0%
  • Molecular Weight:144.7 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for MDX-1105
  • Experimental Validation Results for MDX-1105
  • MDX-1105 Chemical Structure
    MDX-1105 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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MDX-1105 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Flow cytometric analysis of 1X106 500 ng/mL Ionomycin (HY-13434) and 20 ng/mL PMA (HY-18739) co-stimulated Jurkat cells(4h) labeling MDX-1105 (HY-P990623, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.

  • 1/16

    Immobilized Human B7-H1/PD-L1/CD274, Fc Tag can bind MDX-1105. The EC50 for this effect is 16.78 ng/mL.

  • MDX-1105 Chemical Structure
    1/16
  • MDX-1105
  • Flow cytometric analysis of 1X106 500 ng/mL Ionomycin (HY-13434) and 20 ng/mL PMA (HY-18739) co-stimulated Jurkat cells(4h) labeling MDX-1105 (HY-P990623, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.
  • Immobilized Human B7-H1/PD-L1/CD274, Fc Tag can bind MDX-1105. The EC50 for this effect is 16.78 ng/mL.