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Pepinemab

(Synonyms: VX 15/2503)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Pepinemab (VX 15/2503) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), also known as CD100, which is a regulator of neuronal development and plays a role in a variety of cellular processes. Pepinemab can be used in the study of various neurodegenerative diseases such as Alzheimer's disease by blocking the activity of SEMA4D.

For research use only. We do not sell to patients.

  • Purity: ≥99.0%
  • CAS No.: 2097151-87-4
  • Molecular Weight:145.88 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Pepinemab Chemical Structure
  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Experimental Validation Results for Pepinemab
  • Pepinemab Chemical Structure
    Pepinemab Chemical Structure
CAS No.: 2097151-87-4
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Semaphorin-4D/SEMA4D Protein, Human (HEK293, His, HY-P7774) can bind Pepinemab. The EC50 for this effect is 52.14 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with Pepinemab (HY-P99407, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Pepinemab Chemical Structure
    1/16
  • Pepinemab
  • Immobilized Semaphorin-4D/SEMA4D Protein, Human (HEK293, His, HY-P7774) can bind Pepinemab. The EC50 for this effect is 52.14 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells with Pepinemab (HY-P99407, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).