Aur
Three Aurora kinases police chromosome segregation. Aurora A is centrosomal and is activated by binding TPX2; it drives centrosome maturation, spindle assembly and mitotic entry, phosphorylating substrates such as TACC3 and NEDD1. Aurora B is the catalytic subunit of the chromosome passenger complex with INCENP, survivin and borealin, and phosphorylates histone H3 Ser10, MCAK and kinetochore components to destabilize erroneous microtubule attachments while supporting checkpoint signaling and cytokinesis. Aurora C is a meiosis-enriched paralog that partly substitutes for Aurora B. All three are overexpressed in tumors, and inhibitors such as alisertib, barasertib and hesperadin have been evaluated in oncology trials.
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Aur Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
