2'-Deoxyadenosine-13C10
Based on 1 Customer Validation
2'-Deoxyadenosine-13C10 is 13C-labeled 2'-Deoxyadenosine (HY-W040329). 2′-Deoxyadenosine is an adenine nucleoside that inhibits glucose-stimulated insulin release. 2′-Deoxyadenosine inhibits glucose-stimulated increases seen in islet cyclic AMP (cAMP) accumulation. 2'-Deoxyadenosine activates caspase-3 and promotes apoptosis. 2'-Deoxyadenosine inhibits the activity of S-adenosyl-L-homocysteine hydrolase (SAHH). 2'-Deoxyadenosine inhibits the growth of various cells. 2'-Deoxyadenosine has an anticancer effect on colon cancer.
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- Pureté : 99.0%
- Formule: 13C10H13N5O3
- Masse moléculaire:261.17
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 958-09-8
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Appearance Solid
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Masse moléculaire 261.17
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Formule 13C10H13N5O3
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Color White to off-white
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SMILES
O[13C@H]1[13CH]([H])[13C@H](N2[13CH]=N[13C]3=[13C]2N=[13CH]N=[13C]3N)O[13C@@H]1[13CH2]O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (382.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Iain L. Campbell, et al. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J (1982) 204 (3): 689-696. [Content Brief]
[3]. Giannecchini M, et al. 2'-Deoxyadenosine causes apoptotic cell death in a human colon carcinoma cell line. J Biochem Mol Toxicol. 2003;17(6):329-37. [Content Brief]
[4]. Cass CE, et al. Effects of 2'-deoxyadenosine, 9-beta-D-arabinofuranosyladenine, and related compounds on S-adenosyl-L-homocysteine hydrolase activity in synchronous and asynchronous cultured cells. Cancer Res. 1982 Dec;42(12):4991-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8289 mL | 19.1446 mL | 38.2892 mL | 95.7231 mL |
| 5 mM | 0.7658 mL | 3.8289 mL | 7.6578 mL | 19.1446 mL | |
| 10 mM | 0.3829 mL | 1.9145 mL | 3.8289 mL | 9.5723 mL | |
| 15 mM | 0.2553 mL | 1.2763 mL | 2.5526 mL | 6.3815 mL | |
| 20 mM | 0.1914 mL | 0.9572 mL | 1.9145 mL | 4.7862 mL | |
| 25 mM | 0.1532 mL | 0.7658 mL | 1.5316 mL | 3.8289 mL | |
| 30 mM | 0.1276 mL | 0.6382 mL | 1.2763 mL | 3.1908 mL | |
| 40 mM | 0.0957 mL | 0.4786 mL | 0.9572 mL | 2.3931 mL | |
| 50 mM | 0.0766 mL | 0.3829 mL | 0.7658 mL | 1.9145 mL | |
| 60 mM | 0.0638 mL | 0.3191 mL | 0.6382 mL | 1.5954 mL | |
| 80 mM | 0.0479 mL | 0.2393 mL | 0.4786 mL | 1.1965 mL | |
| 100 mM | 0.0383 mL | 0.1914 mL | 0.3829 mL | 0.9572 mL |
2'-Deoxyadenosine-13C10 Related Classifications
HY-W040329S1 Related Classifications
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