FTI 276
FTI-276 is a protein farnesyl transferase (PFT) inhibitor with IC50s of 0.9 and 0.5 nM for Plasmodium falciparum and human.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (FTI 276 TFA) that retains the same biological activity.
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- CAS No.: 170006-72-1
- Formule: C21H27N3O3S2
- Masse moléculaire:433.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Other In-stock Forms of FTI 276
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-10502
TipifarnibFTase Inhibitor -
HY-16273A
L-778123 hydrochlorideFarnesyl Transferase Inhibitor -
HY-16111
BMS-214662Farnesyl Transferase Inhibitor -
HY-16373
CP-609754Farnesyltransferase Inhibitor -
HY-10502A
Tipifarnib (S enantiomer) -
HY-15136
LonafarnibFarnesyltransferase Inhibitor -
HY-10502R
Tipifarnib (Standard)Reference Standard -
HY-15872
FTI-277Farnesyl Transferase Inhibitor -
HY-15872A
FTI-277 hydrochlorideFTase Inhibitor -
HY-100313
YM-53601 free baseSqualene Synthetase Inhibitor -
HY-128350
FGTI-2734Farnesyl/Geranylgeranyl Transferase Inhibitor -
HY-15136R
Lonafarnib (Standard)Reference Standard
Activité biologique
Description
IC50 & Target
IC50: 0.9 and 0.5 nM for Plasmodium falciparum and human[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
>10000 nM
Compound: Hamilton FTI
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Inhibition of human adenocarcinoma cell line Caco-2 proliferation
Inhibition of human adenocarcinoma cell line Caco-2 proliferation
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[PMID: 11784156] |
| LoVo | IC50 |
50 nM
Compound: Hamilton FTI
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Inhibition of human adenocarcinoma cell line LoVo proliferation
Inhibition of human adenocarcinoma cell line LoVo proliferation
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[PMID: 11784156] |
| NIH3T3 | EC50 |
1 μM
Compound: 1
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Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells
Inhibition of H-ras processing in subconfluent H-Ras-transformed NIH3T3 cells
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[PMID: 10201832] |
| NIH3T3 | IC50 |
1 μM
Compound: 1 (FTI-276)
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Inhibition of mammalian H-Ras processing in NIH 3T3 cells
Inhibition of mammalian H-Ras processing in NIH 3T3 cells
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[PMID: 11277514] |
| NIH3T3 | ED50 |
>25 μM
Compound: FTI-276
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Effective dose against murine 3T3 fibroblasts cells
Effective dose against murine 3T3 fibroblasts cells
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[PMID: 14711313] |
| NIH3T3 | ED50 |
1 μM
Compound: 1
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Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.
Inhibition of Ha-Ras processing in NIH3T3 Ras transformed cells.
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[PMID: 9784104] |
Chemical Information
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CAS No. 170006-72-1
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Masse moléculaire 433.59
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Formule C21H27N3O3S2
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SMILES
O=C(O)[C@@H](NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O)CCSC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTI 276 Related Classifications
HY-15873 Related Classifications
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