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GCN2-IN-1

27 Cited Publications
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Based on 27 publication(s) in Google Scholar

GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay.

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  • Pureté: 99.46%
  • CAS No.: 1448693-69-3
  • Formule: C19H18N10O
  • Masse moléculaire:402.41
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • GCN2-IN-1 Chemical Structure
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • GCN2-IN-1 Chemical Structure
    GCN2-IN-1 Chemical Structure
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
  • Experimental Validation Results for GCN2-IN-1
CAS No.: 1448693-69-3
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  • GCN2-IN-1 Chemical Structure
    GCN2-IN-1 Chemical Structure
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    GCN2-IN-1 purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Nov;27(11):1889-1901. [Abstract]

    Customer Validation
     Ubiquitylation of whole-cell proteins and OMM proteins of cells cultured in medium supplemented with 0 mM or 1 mM Leu and/or 0 µM or 10 µM GCN2-IN-1 for 3 h. For each sample, 10 µg proteins were loaded. Ubiquitylation levels were normalized to the total OMM protein amount.

  • 1/16

    GCN2-IN-1 purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2024 May 22;52(9):5356-5375. [Abstract]

    Customer Validation
     U2OS cells were treated with a PERK inhibitor (GSK II, 40 μM), or with GCN2-IN-1 (4 μM), for 3 h prior to transfection. mRNA (1 μg) encoding GFP (green) was transfected, and cells were fixed 1.5 h post-transfection. Cells were stained using anti-G3BP1 (magenta).

  • 1/16

    GCN2-IN-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Oct 25;14(1):6777. [Abstract]

    Customer Validation
     MDA-MB 231 cells were cultured for 72 hours in complete medium (CM) and medium containing 25% amino acids (low amino acid). Then, they were treated with (+) or (-) 1 μM GCN2-IN-1 for 72 hours, respectively, and Western blot analysis was performed to detect the expression of the proteins shown.

  • 1/16

    GCN2-IN-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 8;14(1):5535. [Abstract]

    Customer Validation
     After treating HeLa cells with the GCN2 inhibitor GCN2-IN-1 (A92) at progressively increasing concentrations for 5 hours, the specified proteins in the lysate were analyzed by immunoblotting.

  • 1/16

    GCN2-IN-1 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2023 Jul;30(7):1666-1678. [Abstract]

    Customer Validation
     Immunoblotting of phosphorylated eIF2a (ser51) following treatment of A549 with CuET (2 h) +/–PERK inhibitor combined with siRNA against HRI or GCN2-IN-1 (10 μM; 30 min). Numbers below the blot indicate the signal ratio p-eIF2a/β-actin.

  • GCN2-IN-1