Neuromedin B
Based on 1 publication(s) in Google Scholar
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
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- Pureté: 99.22%
- CAS No.: 87096-84-2
- Formule: C52H73N15O12S
- Masse moléculaire:1132.29
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Neuromedin B
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Activité biologique
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
120 nM
Compound: 2 (NMB)
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Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
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[PMID: 12723954] |
| CHO | EC50 |
41 nM
Compound: 2 (NMB)
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Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assay
Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assay
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[PMID: 12723954] |
| CHO | EC50 |
4500 nM
Compound: 2 (NMB)
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Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.
Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.
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[PMID: 12723954] |
Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87096-84-2
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Appearance Solid
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Masse moléculaire 1132.29
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Formule C52H73N15O12S
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Color White to off-white
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Sequence
Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
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Sequence Shortening
GNLWATGHFM-NH2
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pathol Res Pract
Effect of NMB-regulated ERK1/2 and p65 signaling pathway on proliferation and apoptosis of cervical cancer. [Abstract]2022 Oct:238:154104. PMID: 36095918
Solvant et solubilité
H2O : 2 mg/mL (1.77 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8832 mL | 4.4158 mL | 8.8317 mL | 22.0791 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Neuromedin B Related Classifications
HY-P0241 Related Classifications
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