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Cat. No.: HY-176938

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AfaPhos1

AfaPhos1 is a new, Afatinib (HY-10261)-based EGFR PhosTAC. AfaPhos1 induces EGFR dephosphorylation at both pY1068 and pY845. AfaPhos1 induces Apoptosis. AfaPhos1 has anticancer activity against non-small cell lung cancer.

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Formule: C₆₄H₇₇ClFN₇O₁₄
Masse moléculaire:1222.79

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

AfaPhos1 Chemical Structure

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

Chemical Information

Masse moléculaire 1222.79
Formule C₆₄H₇₇ClFN₇O₁₄
SMILES

O=C(COC1=CC([C@@H](CCC2=CC=C(C(OC)=C2)OC)OC([C@@H]3CCCCN3C([C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC)=O)=O)=CC=C1)NCCOCCOCCN(C/C=C/C(NC5=CC6=C(C=C5OC)N=CN=C6NC7=CC=C(C(Cl)=C7)F)=O)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hu Z, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10(13):eadj7251. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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AfaPhos1

Voir tous les produits spécifiques à Isoform EGFR