ALX-5407
ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 571147-18-7
- Formule: C24H24FNO3
- Masse moléculaire:393.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
3 nM
Compound: ALX-5407
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Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
Inhibition of [3H]glycine uptake at rat glycine transporter 1 expressed in african green monkey COS7 cells
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[PMID: 19013063] |
| JAR | IC50 |
0.39 nM
Compound: ALX5407
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Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
Inhibition of GlyT1 in human JAR cells assessed as inhibition of [3H]glycine uptake preincubated for 1 mins measured after 2 hrs by liquid scintillation counting
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[PMID: 21975065] |
| T98G | IC50 |
4.8 nM
Compound: ALX-5407
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Inhibition of [3H]glycine uptake in human T98G cells
Inhibition of [3H]glycine uptake in human T98G cells
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[PMID: 19013063] |
ALX-5407 (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [3H]glycine uptake in rat brain and QT6-1C cells with an IC50 value of 3 nM[1]. ALX-5407 (50 nM) shows slow dissociation kinetics in QT6-1C cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 571147-18-7
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Masse moléculaire 393.45
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Formule C24H24FNO3
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SMILES
OC(CN(C)CC[C@H](C1=CC=C(C=C1)F)OC2=CC=C(C3=CC=CC=C3)C=C2)=O
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Synonyms
(R)-NFPS
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALX-5407 Related Classifications
HY-10711 Related Classifications
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