Anticancer agent 127
Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects.
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- CAS No.: 2410953-19-2
- Formule: C26H37FN4O6S
- Masse moléculaire:552.66
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | EC50 |
44 nM
Compound: 142D6
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Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging analysis
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by IncuCyte live-cell imaging analysis
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[PMID: 37262387] |
| MDA-MB-231 | EC50 |
61 nM
Compound: 142D6
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Induction of apoptosis in human MDA-MB-231 cells
Induction of apoptosis in human MDA-MB-231 cells
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[PMID: 37262387] |
| MDA-MB-231 | EC50 |
94.2 nM
Compound: 142D6
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Cytotoxicity against human MDA-MB-231 cells cultured as 3D spheroids incubated for 6 days and measured every 6 hrs by IncuCyte live-cell analysis
Cytotoxicity against human MDA-MB-231 cells cultured as 3D spheroids incubated for 6 days and measured every 6 hrs by IncuCyte live-cell analysis
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[PMID: 37262387] |
Chemical Information
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CAS No. 2410953-19-2
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Masse moléculaire 552.66
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Formule C26H37FN4O6S
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SMILES
O=C(N1[C@H](C(N[C@H]2C(C=CC=C3OS(=O)(F)=O)=C3CC2)=O)CCC1)[C@H](C4CCCCC4)NC([C@H](C)NC)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 127 Related Classifications
HY-155018 Related Classifications
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