Anticancer agent 329
Anticancer agent 329 is a mitochondria-targeted Podophyllotoxin (HY-15552) derivative conjugated with F16 (HY-100395), and also acts as an anticancer agent. Anticancer agent 329 accumulates in mitochondria and induces Apoptosis in a concentration-dependent manner. Anticancer agent 329 can be used in the research of liver cancer, colorectal cancer, non-small cell lung cancer and breast cancer.
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- CAS No.: 3128226-38-7
- Formule: C45H47BrN2O9
- Masse moléculaire:839.77
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vitro
Anticancer agent 329 (Compound 6d) potently inhibits the proliferation of HepG2, HCT116, A549, and MDA-MB-231 cells with IC50 values of 0.66 μM, 1.10 μM, 2.00 μM, and 3.31 μM respectively, and exhibits a selectivity index of 2.29 for HepG2 cells over normal QSG-7701 hepatocytes[1].
Anticancer agent 329 (1.2-4.8 μM; 24 h) induces apoptosis in HepG2 cells in a concentration-dependent manner, with total apoptosis rates reaching 17.79% at a 4.8 μM 24-hour treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3128226-38-7
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Masse moléculaire 839.77
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Formule C45H47BrN2O9
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SMILES
O=C(OC1)[C@@H]([C@H]1[C@H]2OC(CCCCCCC[N+]3=CC=C(/C=C/C4=CNC5=C4C=CC=C5)C=C3)=O)[C@H](C6=CC(OC)=C(OC)C(OC)=C6)C(C2=C7)=CC8=C7OCO8.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 329 Related Classifications
HY-184280 Related Classifications
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