Anticancer agent 330
Anticancer agent 330 is a semi-synthetic derivative of Salinomycin (HY-15597) conjugated with triphenylphosphine, as well as an anticancer agent. Anticancer agent 330 induces G0/G1 phase cell cycle arrest. Anticancer agent 330 reduces the production of ROS in cells. Anticancer agent 330 impairs mitochondrial integrity. Anticancer agent 330 promotes Autophagy. Anticancer agent 330 can be used in research related to ovarian cancer.
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- CAS No.: 3127025-65-1
- Formule: C63H87BrN3O10P
- Masse moléculaire:1157.26
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Anticancer agent 330 (Compound 8) (72 h) exhibits cytotoxic activity comparable to that of Salinomycin (HY-15597) in the A2780, Caov3, OVCAR3, SKOV3 ovarian cancer cell lines and MRC-5 pd19 fibroblasts, and shows improved selectivity towards A2780 and OVCAR3 cells compared with Salinomycin[1].
Combination treatment with anticancer agent 330 (72 h) and Carboplatin (HY-17393) produces nearly additive interactions in A2780, OVCAR3 and SKOV3 ovarian cancer cell lines, induces moderate antagonistic effects in Caov3 ovarian cancer cells, and exerts differential impacts on cell viability across different cell lines[1].
Anticancer agent 330 (72 h) regulates the expression of apoptosis- and cell cycle-related proteins in a cell line-dependent manner in A2780, Caov3, OVCAR3 and SKOV3 ovarian cancer cell lines, and its effects when used alone or in combination with Carboplatin are similar to those of Salinomycin[1].
Anticancer agent 330 regulates ROS production and disrupts mitochondrial membrane potential in a cell line-dependent manner, and this effect involves the A2780, Caov3, OVCAR3 and SKOV3 ovarian cancer cell lines; its efficacy when used alone or in combination with Carboplatin is similar to that of Salinomycin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3127025-65-1
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Masse moléculaire 1157.26
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Formule C63H87BrN3O10P
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SMILES
[H][C@]1(O[C@H](CC[C@@H]1C)[C@H](C(O)=O)CC)[C@H]([C@@H]([C@@H](C([C@@H]([C@H]2O[C@@]3([C@@H](C[C@@H]2C)C)C=CC([C@@]4(O3)CC[C@@]([C@H]5CC[C@](CC)([C@@H](O5)C)O)(O4)C)N6C=C(N=N6)C[P+](C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9)CC)=O)C)O)C.[Br-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 330 Related Classifications
HY-184338 Related Classifications
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- Anticancer agent 330
- 3127025-65-1
- Anticancer agent330
- Anticancer agent-330
- Drug Derivative
- Reactive Oxygen Species (ROS)
- Mitochondrial Metabolism
- Autophagy
- mitochondrial integrity
- SKOV3
- ovarian cancer cells
- ovarian cancer
- reactive oxygen species
- A2780
- G0/G1 cell cycle arrest
- OVCAR3
- Caov3
- autophagy
- Inhibitor
- inhibitor
- inhibit