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Cat. No.: HY-10364

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AP24163

AP24163 is a BCR-ABL kinase inhibitor. AP24163 inhibits wild-type (native) BCR-ABL and BCR-ABL-T315I with IC₅₀ values of 7 nM and 511 nM, respectively. AP24163 can be used in the research of chronic myeloid leukemia (CML).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 926922-16-9
Formule: C₂₉H₂₅F₃N₈O
Masse moléculaire:558.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

AP24163 Chemical Structure

CAS No.: 926922-16-9

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Protocole (1)
Pureté et documentation
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Bcr-Abl :

Abl
Bcr-Abl

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	24 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl E255K mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	42 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Q252H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl T315I mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	422 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing ABL T315I mutant after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	44 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl Y253H mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	63 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl G250E mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	64 nM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing Bcr-Abl L248R mutant after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	6455 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells after 3 days by MTS assay	[PMID: 19572547]
BaF3	IC₅₀	7.3 nM Compound: la	Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type ABL after 3 days by MTS assay	[PMID: 20513156]
BaF3	IC₅₀	7.3 μM Compound: 14a, AP24163	Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay Antiproliferative activity against mouse BA/F3 cells expressing wild type Bcr-Abl after 3 days by MTS assay	[PMID: 19572547]
K562	IC₅₀	4.3 μM Compound: 14a, AP24163	Antiproliferative activity against human K562 cells after 3 days by MTS assay Antiproliferative activity against human K562 cells after 3 days by MTS assay	[PMID: 19572547]

Chemical Information

CAS No. 926922-16-9
Masse moléculaire 558.56
Formule C₂₉H₂₅F₃N₈O
SMILES

O=C(NC1=CC(N2C=NC(C)=C2)=CC(C(F)(F)F)=C1)C3=CC(/C=C/N4C5=NC=NC(NC6CC6)=C5N=C4)=C(C)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (240 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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