Bletilloside A
Based on 1 Customer Validation
Bletilloside A is a glycoside. Bletilloside A can be isolated from the tubers of Bletilla striata. Bletilloside A inhibits the expression of the TCL1A protein. When evaluated for its inhibitory activity against LPS-induced NO, Bletilloside A shows an IC50 of >70 μM. Bletilloside A exhibits anticancer activity against acute myeloid leukemia. Bletilloside A can be used in studies related to acute myeloid leukemia.
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- Pureté: 99.88%
- CAS No.: 2292159-89-6
- Formule: C29H36O15
- Masse moléculaire:624.59
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
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Activité biologique
Bletilloside A (1-128 μM; 48 h) inhibits the proliferation of three acute myeloid leukemia cell lines, SKNO-1, MV4-11 and HL-60[1].
Bletilloside A (30-60 μM) reduces the expression of TCL1A protein in SKNO-1 and HL-60 acute myeloid leukemia (AML) cell lines[1].
Bletilloside A (0-240 μM; 24 h) shows no cytotoxicity against RAW 264.7 macrophages, with a CC50 >240 μM[2].
Bletilloside A (1 h) exhibits an IC50 of >70 μM when evaluated for its LPS-induced NO inhibitory activity in RAW 264.7 macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human AML cell lines SKNO-1, MV4-11, HL-60
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Concentration:1-128 μM
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Incubation Time:48 h
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Result:Significantly inhibited the proliferation of SKNO-1, MV4-11, and HL-60 AML cells, with IC60 values of 29.906 μM, 36.410 μM, and 89.395 μM, respectively.
Chemical Information
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CAS No. 2292159-89-6
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Appearance Solid
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Masse moléculaire 624.59
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Formule C29H36O15
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Color White to off-white
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SMILES
COC1=C(C=CC(/C=C/C(OCC(C=C2)=CC=C2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)=O)=C1)O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Hong Y, et al. New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein. BMC Cancer. 2025;26(1):91. Published 2025 Dec 10. [Content Brief]
[2]. Zhao Y, et al. Chemical constituents from Bletilla striata and their NO production suppression in RAW 264.7 macrophage cells. J Asian Nat Prod Res. 2018;20(4):385-390. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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