BPN-01
BPN-01 is a fluorescent probe targeting translocator protein (TSPO) and human epidermal growth factor receptor 2 (HER2) with binding affinities of -10.7 kcal/mol for TSPO and -11.3 kcal/mol for HER2. BPN-01 is promising for research of solid tumor imaging during fluorescence image-guided surgery (FIGS) (Ex/Em = 475/510 nm).
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- Formule: C22H16N6O5S
- Masse moléculaire:476.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
BPN-01 (3.91 μg/mL, 7.81 μg/mL, 15.63 μg/mL, 31.25 μg/mL, 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL; 48 h; B16-F10) maintains B16-F10 cell viability at ~100% across all concentrations[1].
BPN-01 (0.01 mM, 0.05 mM, 0.1 mM, 0.5 mM, 1.0 mM; 24 h; DU-145, B16-F10, C2C12) stains DU-145 and B16-F10 cancer cells at 0.01 mM but not at higher concentrations or in C2C12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 476.46
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Formule C22H16N6O5S
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SMILES
COC1=CC=C2C(SC(C(NC3=CC=C(C=C3)CNC4=CC=C(C5=NON=C45)[N+]([O-])=O)=O)=N2)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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