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Cat. No.: HY-123312

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CK-548

Name: CK-548
Brand: MedChemExpress
SKU: HY-123312
Price: 160.00 USD
Availability: PreOrder

(Synonyms: CK-0993548)

CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC₅₀ of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection.

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CAS No.: 388604-55-5
Formule: C₁₅H₁₁BrClNO₂S
Masse moléculaire:384.68

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

CK-548 Chemical Structure

CAS No.: 388604-55-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

CK-548 (CK-0993548) is a Arp2/3 complex inhibitor with the IC₅₀ of 11 μM. CK-548 inhibits HIV-1 nuclear migration and infection^[1]^[2].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	9.95 μM Compound: 1, CK-548	Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 24794770]
MDA-MB-231	IC₅₀	26.98 μM Compound: 1, CK-548	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 24794770]

Chemical Information

CAS No. 388604-55-5
Appearance Solid
Masse moléculaire 384.68
Formule C₁₅H₁₁BrClNO₂S
Color White to off-white
SMILES

O=C1N(C(SC1)C2=CC=CC(Br)=C2)C3=CC(Cl)=CC=C3O
Synonyms

CK-0993548
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (596 KB)
- English - EN (596 KB)
- Français - FR (596 KB)
- Deutsch - DE (596 KB)
- Norwegian - NO (596 KB)
- Español - ES (596 KB)
- Swedish - SV (596 KB)
- Italian - IT (596 KB)
- Korean - KR (596 KB)
- Portuguese - PT (596 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. B. J. Nolen, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature.

[2]. Spear M, et al. HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. J Biol Chem. 2014;289(10):6949-6959. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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CK-548

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