CL-283796
CL-283796 is a potent and orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research.
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- CAS No.: 107376-72-7
- Formule: C28H41ClN2O
- Masse moléculaire:457.09
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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ACAT |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult African green monkeys fed an atherogenic diet for approximately 6 weeks[1]
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Dosage:10 and 30 mg/kg
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Administration:p.o., 10 mg/kg daily for 5 weeks and 30 mg/kg daily for the next 5 weeks
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Result:Resulted in a 24.1% reduction in total plasma cholesterol after 30 days (10 mg/kg dose).
Resulted in significant reductions in LDL cholesterol but non-significant effects on VLDL cholesterol values.
Showed no significant effects on plasma triglyceride values, HDL cholesterol, and apolipoproteins A-I, B and E levels.
Decreased the total plasma cholesterol (TPC)/HDL cholesterol ratios by 40% after 10 weeks.
Showed no significant effect on cholesterol absorption.
Did not affect body weights.
Chemical Information
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CAS No. 107376-72-7
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Masse moléculaire 457.09
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Formule C28H41ClN2O
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SMILES
O=C(NC1=C(C)C=C(Cl)C=C1C)N(CCCCCCC)CC2=CC=C(CCC(C)C)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CL-283796 Related Classifications
HY-19251 Related Classifications
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