Cymserine
Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC50 value of 56.43 nM and a Ki of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease.
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- CAS No.: 145209-39-8
- Formule: C23H29N3O2
- Masse moléculaire:379.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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BuChE 38 nM (Ki) |
Cymserine (0.02-0.12 μM; 0-60 min) potently inhibits purified human BuChE with an IC50 range of 63-100 nM (depending on substrate concentration), a minimum IC50 of 56.43 nM, and a Ki of 38 nM, and exhibits time-dependent binding activity loss with a critical 50% activity loss time of 7.54 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 145209-39-8
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Masse moléculaire 379.50
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Formule C23H29N3O2
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SMILES
C[C@]12C3=CC(OC(NC4=CC=C(C=C4)C(C)C)=O)=CC=C3N([C@@]1([H])N(CC2)C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cymserine Related Classifications
HY-182615 Related Classifications
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