Cytostatin
Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin.
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- CAS No.: 682329-63-1
- Formule: C21H33O7P
- Masse moléculaire:428.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
PP2A[1]
Chemical Information
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CAS No. 682329-63-1
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Masse moléculaire 428.46
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Formule C21H33O7P
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SMILES
O=C1C=C[C@H](C)[C@H]([C@@H](C)CC[C@H](OP(O)(O)=O)[C@@H](C)[C@@H](O)/C=C\C=C/C=C/C)O1
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Structure Classification
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Initial Source
fostriecin
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lawhorn BG, et al. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. J Am Chem Soc. 2006;128(51):16720-16732. [Content Brief]
[2]. Kawada M, et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim Biophys Acta. 1999;1452(2):209-217. [Content Brief]
[3]. Kawada M, et al. Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin. Jpn J Cancer Res. 1999;90(2):219-225. [Content Brief]
[4]. Bialy L, et al. Total synthesis and biological evaluation of the protein phosphatase 2A inhibitor cytostatin and analogues. Chemistry. 2004;10(11):2759-2780. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cytostatin Related Classifications
HY-113612 Related Classifications
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