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Dargistotug

(Synonyms: M-6223)
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Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function.

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  • Pureté: 99.36%
  • CAS No.: 2649362-29-6
  • Masse moléculaire:1.47 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Dargistotug
  • Experimental Validation Results for Dargistotug
  • Experimental Validation Results for Dargistotug
  • Dargistotug Chemical Structure
    Dargistotug Chemical Structure
CAS No.: 2649362-29-6
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Dargistotug Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized TIGIT Protein, Human can bind Dargistotug. The EC50 for this effect is 20.41 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 FaDu cells with Dargistotug (HY-P990031, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Dargistotug Chemical Structure
    1/16
  • Dargistotug
  • Immobilized TIGIT Protein, Human can bind Dargistotug. The EC50 for this effect is 20.41 ng/mL.
  • Flow cytometric analysis of 1X106 FaDu cells with Dargistotug (HY-P990031, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).