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Cat. No.: HY-N19749

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Decumbensine

(Synonyms: (+)-Decumbensine; (+)-Egenine)

Decumbensine ((+)-Egenine) is a phthalideisoquinoline hemiacetal alkaloid present in Corydalis decumbens. Decumbensine significantly inhibits spontaneous calcium oscillations in primary cultured neocortical neurons, reducing oscillation frequency and amplitude. Decumbensine can be used in studies related to central nervous system diseases, epilepsy and pain.

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CAS No.: 6883-44-9
Formule: C₂₀H₁₉NO₆
Masse moléculaire:369.37

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Decumbensine Chemical Structure

CAS No.: 6883-44-9

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Description

Decumbensine ((+)-Egenine) is a phthalideisoquinoline hemiacetal alkaloid present in Corydalis decumbens^[1]^[2]^[3]. Decumbensine significantly inhibits spontaneous calcium oscillations in primary cultured neocortical neurons, reducing oscillation frequency and amplitude^[2]. Decumbensine can be used in studies related to central nervous system diseases, epilepsy and pain^[1]^[2].

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In Vitro

Decumbensine (6.8 μM) potently inhibits spontaneous calcium oscillations in primary cultured neocortical neurons with an IC₅₀ of 6.8 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6883-44-9
Masse moléculaire 369.37
Formule C₂₀H₁₉NO₆
SMILES

CN1[C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)[C@H](O4)O
Synonyms

(+)-Decumbensine; (+)-Egenine
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Zhang JS,et al. Decumbensine and epi-α-Decumbensine: Two New Alkaloids Isolated from Corydalis decumbens. J Nat Prod. 1988 Nov-Dec;51(6):1241-1242.

[2]. Zhang CL,et al. Phthalideisoquinoline Hemiacetal Alkaloids from Corydalis decumbens That Inhibit Spontaneous Calcium Oscillations, Including Alkyl Derivatives of (+)-Egenine That Are Strikingly Levorotatory. J Nat Prod. 2019 Oct 25;82(10):2713-2720. [Content Brief]

[3]. Chang J,et al. Two novel isoquinoline alkaloids from the seedling of Corydalis decumbens. Tetrahedron Lett. 2015 Jan 1;56(1):225-228. doi: 10.1016/j.tetlet.2014.11.066.

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Decumbensine

Voir tous les produits spécifiques à Isoform Calcium Channel

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Decumbensine Related Classifications

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