Deoxyfrenolicin
Deoxyfrenolicin is a quinone antibiotic that can be isolated from the fermentation broth of the Streptomyces roseofulvus strain AM-3867. Deoxyfrenolicin belongs to the frenolicin class of antibiotics. Deoxyfrenolicin exhibits antibacterial activity in vitro and can effectively inhibit the activity of Mycoplasma gallisepticum.
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- CAS No.: 10023-11-7
- Formule: C18H18O6
- Masse moléculaire:330.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.07 μM
Compound: 9
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Cytotoxicity against human A549 cells after 2 days by MTT assay
Cytotoxicity against human A549 cells after 2 days by MTT assay
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[PMID: 23944931] |
| MDA-MB-468 | IC50 |
0.33 μM
Compound: 5, deoxyfrenolicin
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Cytotoxicity against human MDA468 cells expressing AKT
Cytotoxicity against human MDA468 cells expressing AKT
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[PMID: 19309081] |
Chemical Information
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CAS No. 10023-11-7
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Masse moléculaire 330.33
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Formule C18H18O6
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SMILES
CCC[C@@H]1C2=C(C[C@H](O1)CC(O)=O)C(C3=CC=CC(O)=C3C2=O)=O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Deoxyfrenolicin Related Classifications
HY-N14134 Related Classifications
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