DHPS-IN-3
Based on 1 Customer Validation
DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC50 of 0.0092 μM at 14 μM NAD and an IC50 of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 97.13%
- CAS No.: 2470012-40-7
- Formule: C18H23N3OS
- Masse moléculaire:329.46
-
Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
Description
In Vitro
DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC50 of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
Chemical Information
-
CAS No. 2470012-40-7
-
Appearance Solid
-
Masse moléculaire 329.46
-
Formule C18H23N3OS
-
Color Off-white to pink
-
SMILES
O=C1C2=C(CCN1[C@@H](CN)CC(C)C)C(C3=CN=CC=C3)=CS2
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (303.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
-
Fiche technique (285 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0353 mL | 15.1763 mL | 30.3527 mL | 75.8817 mL |
| 5 mM | 0.6071 mL | 3.0353 mL | 6.0705 mL | 15.1763 mL | |
| 10 mM | 0.3035 mL | 1.5176 mL | 3.0353 mL | 7.5882 mL | |
| 15 mM | 0.2024 mL | 1.0118 mL | 2.0235 mL | 5.0588 mL | |
| 20 mM | 0.1518 mL | 0.7588 mL | 1.5176 mL | 3.7941 mL | |
| 25 mM | 0.1214 mL | 0.6071 mL | 1.2141 mL | 3.0353 mL | |
| 30 mM | 0.1012 mL | 0.5059 mL | 1.0118 mL | 2.5294 mL | |
| 40 mM | 0.0759 mL | 0.3794 mL | 0.7588 mL | 1.8970 mL | |
| 50 mM | 0.0607 mL | 0.3035 mL | 0.6071 mL | 1.5176 mL | |
| 60 mM | 0.0506 mL | 0.2529 mL | 0.5059 mL | 1.2647 mL | |
| 80 mM | 0.0379 mL | 0.1897 mL | 0.3794 mL | 0.9485 mL | |
| 100 mM | 0.0304 mL | 0.1518 mL | 0.3035 mL | 0.7588 mL |
DHPS-IN-3 Related Classifications
HY-182529 Related Classifications
Powered by Bioz