Dicentrinone
Dicentrinone is an orally active PDI inhibitor with an IC50 value of 43.95 μM. Dicentrinone directly binds to PDI and suppresses cell proliferation and reduces cancer cell viability. Dicentrinone elicits anti-inflammatory and antioxidant effects by suppressing leukocyte migration, plasma leakage and paw edema, and scavenging free radicals. Dicentrinone can be used in the research of hepatoma, rheumatism and arthritis.
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- CAS No.: 16408-78-9
- Formule: C19H13NO5
- Masse moléculaire:335.31
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Stockage:
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| HCT-116 | IC50 |
10 μM
Compound: 9
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Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay
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[PMID: 31403289] |
Dicentrinone (compound 1) (1-100 μM; 48 h) potently suppresses HepG2 cell proliferation with a CC50 of 20.70 μM[1].
Dicentrinone (3-300 μM; 1 h) inhibits purified bovine PDI activity with an IC50 of 56.70 μM[1].
Dicentrinone (56.70 μM; 48 h) suppresses HepG2 cell viability specifically through inhibition of PDI, as co-treatment with PDI siRNA does not enhance its cytotoxic effect[1].
Dicentrinone (72 h) does not inhibit the growth of MCF-7, HCT116, HepG2, HL-60, or MRC-5 cells, with IC50 >10 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human hepatoma HepG2 cells
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Concentration:log0, log0.5, log1, log1.5, log2 μM
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Incubation Time:48 h
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Result:Reduced HepG2 cell viability in a dose-dependent manner: at 1 μM, cell viability was 75.29%; at 10 μM, cell viability was 59.98%; at 50 μM, cell viability was 11.79%.
Calculated the 50% cytotoxic concentration (CC50) as 20.70 μM.
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Cell Line:human hepatoma HepG2 cells
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Concentration:56.70 μM
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Incubation Time:48 h (siRNA transfection prior to treatment)
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Result:Reduced the cell number index to 0.54 in the siCtl group compared to untreated siCtl cells.
Showed no further reduction of cell number index when co-treated with siPDI compared to siPDI alone.
Dicentrinone (100 mg/kg; p.o.) inhibits Carrageenan-induced leukocyte migration by 69.1% and plasma leakage by 50.4% in the Swiss mouse air pouch inflammation model[3].
Dicentrinone (100 mg/kg; p.o.) significantly inhibits zymosan-induced leukocyte recruitment and articular edema in male mice via intra-articular induction[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 16408-78-9
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Masse moléculaire 335.31
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Formule C19H13NO5
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SMILES
O=C1C2=NC=CC3=CC4=C(C(C5=C1C=C(OC)C(OC)=C5)=C23)OCO4
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[2]. Paz WHP, et al. Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis. J Nat Prod. 2019 Aug 23;82(8):2220-2228. [Content Brief]
[3]. do Santos RC, et al. Antioxidant, anti-rheumatic and anti-inflammatory investigation of extract and dicentrinone from Duguetia furfuracea (A. St.-Hil.) Benth. & Hook. f. J Ethnopharmacol. 2018 Jan 30;211:9-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dicentrinone Related Classifications
HY-N19464 Related Classifications
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