DS01080522
DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.
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- CAS No.: 2832159-84-7
- Formule: C23H20Cl2N4O3
- Masse moléculaire:471.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation)[1]
DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH/3T3 cells
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Concentration:1-10 μM
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Incubation Time:30 min
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Result:Dose-dependently decreased the phosphorylation level of CREB which is a marker of intracellular PRAKACA inhibitory activity in NIH/3T3 cells with an IC50 value of 66 nM.
Chemical Information
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CAS No. 2832159-84-7
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Masse moléculaire 471.34
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Formule C23H20Cl2N4O3
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SMILES
O=C(N[C@H]([C@@]1([H])C[C@H](O)CN1)C2=CC(Cl)=C(C#N)C=C2)C3=CC4=CC=NC(Cl)=C4C=C3OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS01080522 Related Classifications
HY-150073 Related Classifications
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