EAAT2 activator 1
Based on 1 Customer Validation
EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 is the major glutamate transporter and functions to remove glutamate from synapses. EAAT2 activator 1 increases EAAT2 protein levels dose-dependently.
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- Pureté: 98.23%
- CAS No.: 892415-28-0
- Formule: C16H11ClFN3S
- Masse moléculaire:331.80
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-12741
LDN-212320 -
HY-107523A
WAY-213613 hydrochloride -
HY-107522
DL-TBOA -
HY-107523
WAY-213613 -
HY-114381
GT 949 -
HY-100784
Dihydrokainic acid -
HY-107521
TFB-TBOA -
HY-107523AR
WAY-213613 hydrochloride (Standard) -
HY-10914
UCPH-101 -
HY-118858
UCPH-102 -
HY-100784R
Dihydrokainic acid (Standard) -
HY-100801
L-threo-3-Hydroxyaspartic acid
Activité biologique
Description
IC50 & Target
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EAAT2 |
Chemical Information
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CAS No. 892415-28-0
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Appearance Solid
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Masse moléculaire 331.80
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Formule C16H11ClFN3S
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Color Light brown to brown
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SMILES
FC1=CC=CC(Cl)=C1CSC2=CC=C(C3=NC=CC=C3)N=N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (75.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 1.67 mg/mL (5.03 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 1.67 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0139 mL | 15.0693 mL | 30.1386 mL | 75.3466 mL |
| 5 mM | 0.6028 mL | 3.0139 mL | 6.0277 mL | 15.0693 mL | |
| 10 mM | 0.3014 mL | 1.5069 mL | 3.0139 mL | 7.5347 mL | |
| 15 mM | 0.2009 mL | 1.0046 mL | 2.0092 mL | 5.0231 mL | |
| 20 mM | 0.1507 mL | 0.7535 mL | 1.5069 mL | 3.7673 mL | |
| 25 mM | 0.1206 mL | 0.6028 mL | 1.2055 mL | 3.0139 mL | |
| 30 mM | 0.1005 mL | 0.5023 mL | 1.0046 mL | 2.5116 mL | |
| 40 mM | 0.0753 mL | 0.3767 mL | 0.7535 mL | 1.8837 mL | |
| 50 mM | 0.0603 mL | 0.3014 mL | 0.6028 mL | 1.5069 mL | |
| 60 mM | 0.0502 mL | 0.2512 mL | 0.5023 mL | 1.2558 mL |
EAAT2 activator 1 Related Classifications
HY-139692 Related Classifications
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