HOOK2 - hook microtubule tethering protein 2 Gene

Also Known as HK2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29911

About HOOK2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,763,003-12,792,350 (from NCBI)

This gene has 25 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 18.1), duodenum (RPKM 14.2) and 24 other tissues.

Summary

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

HOOK2 Products (9)

mRNA Protein Name
NM_001100176.2 NP_001093646.1 protein Hook homolog 2 isoform 2
NM_001400041.1 NP_001386970.1 protein Hook homolog 2 isoform 3
NM_001400043.1 NP_001386972.1 protein Hook homolog 2 isoform 4
NM_001400044.1 NP_001386973.1 protein Hook homolog 2 isoform 4
NM_001400045.1 NP_001386974.1 protein Hook homolog 2 isoform 4
NM_001400046.1 NP_001386975.1 protein Hook homolog 2 isoform 4
NM_001400047.1 NP_001386976.1 protein Hook homolog 2 isoform 4
NM_001400048.1 NP_001386977.1 protein Hook homolog 2 isoform 4
NM_013312.3 NP_037444.2 protein Hook homolog 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
18799622 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Références Source
involved in early endosome to late endosome transport IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in lysosome organization IMP
IMP: Inferred from mutant phenotype
18799622 GOA
involved in protein localization to perinuclear region of cytoplasm IMP
IMP: Inferred from mutant phenotype
32073997 GOA
Cellular Component GO Annotation Evidence Références Source
part of FHF complex IDA
IDA: Inferred from direct assay
18799622 GOA
part of HOPS complex IDA
IDA: Inferred from direct assay
18799622 GOA
located in centrosome IDA
IDA: Inferred from direct assay
17140400 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
32073997 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOOK2 Protein Structure

HOOK

HOOK: HOOK protein (1 - 710)

  • 0
  • 200
  • 400
  • 600
  • 719 a.a.
Protein Preferred Names Protein Names

protein Hook homolog 2

  • h-hook2

HOOK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
HOOK2 Q96ED9 UTP14C Homo sapiens Q08E77
Y2H Prey Pooling
25416956
Intra
HOOK2 Q96ED9 UTP14C Homo sapiens Q08E77
Validated Y2H
25416956
Intra
HOOK2 Q96ED9 UTP14C Homo sapiens Q08E77
Y2H Array
25416956
Intra
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Y2H
21516116
Intra
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Y2H Prey Pooling
25416956
Intra
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Validated Y2H
25416956
Intra
HOOK2 Q96ED9 SUV39H1 Homo sapiens O43463
Y2H Array
25416956
Intra
HOOK2 Q96ED9 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
25416956
Intra
HOOK2 Q96ED9 CWF19L2 Homo sapiens Q2TBE0
Y2H Prey Pooling
25416956
Intra
HOOK2 Q96ED9 CWF19L2 Homo sapiens Q2TBE0
Validated Y2H
25416956
Intra
HOOK2 Q96ED9 CWF19L2 Homo sapiens Q2TBE0
Y2H Array
25416956
Intra
HOOK2 Q96ED9 FHIP2A Homo sapiens Q5W0V3
Anti Tag CoIP
34882091
Intra
HOOK2 Q96ED9 FHIP2A Homo sapiens Q5W0V3
BioID
34882091
Intra
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H Array
31515488
Intra
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
BioID
34882091
Intra
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H Pooling
16189514
Intra
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H Fragment Pooling
23414517
Intra
HOOK2 Q96ED9 AKTIP Homo sapiens Q9H8T0
Y2H
32073997
Intra
HOOK2 Q96ED9 KANSL1 Homo sapiens Q7Z3B3
Y2H Prey Pooling
25416956
Intra
HOOK2 Q96ED9 KANSL1 Homo sapiens Q7Z3B3
Y2H Array
25416956
Intra
HOOK2 Q96ED9 ZC2HC1C Homo sapiens Q53FD0
Y2H Prey Pooling
25416956
Intra
HOOK2 Q96ED9 ZC2HC1C Homo sapiens Q53FD0
Y2H Array
25416956
Intra
HOOK2 Q96ED9 ZC2HC1C Homo sapiens Q53FD0
Validated Y2H
25416956
Intra
HOOK2 Q96ED9 CCDC33 Homo sapiens Q8N5R6
Y2H Pooling
16189514
Intra
HOOK2 Q96ED9 ANKRD36BP1 Homo sapiens Q96IX9
Y2H Prey Pooling
25416956
Intra
HOOK2 Q96ED9 DUSP13B Homo sapiens Q9UII6
Validated Y2H
25416956
Intra
HOOK2 Q96ED9 DUSP13B Homo sapiens Q9UII6
Y2H Array
25416956
Intra
HOOK2 Q96ED9 DUSP13B Homo sapiens Q9UII6
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

HOOK2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P86904 HOOK2 Antibody (YA6597) WB, IHC-P Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06288 HOOK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HOOK2 RGD RGD:1310171
Canis familiaris HOOK2 VGNC VGNC:41741
Felis catus HOOK2 VGNC VGNC:62833
Macaca mulatta HOOK2 VGNC VGNC:73425
Mus musculus HOOK2 MGD MGI:2181664
Bos taurus HOOK2 VGNC VGNC:29906
Others HOOK2 NCBI