CDCP1 - CUB domain containing protein 1 Gene

Also Known as CD318; TRASK; SIMA135

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64866

About CDCP1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,082,277-45,146,482 (from NCBI)

This gene has 3 transcripts (splice variants) and 269 orthologues. Broad expression in esophagus (RPKM 12.2), skin (RPKM 11.1) and 15 other tissues.

Summary

This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

CDCP1 Products (2)

mRNA Protein Name
NM_022842.5 NP_073753.3 CUB domain-containing protein 1 isoform 1 precursor
NM_178181.3 NP_835488.1 CUB domain-containing protein 1 isoform 2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
21233420 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CUB domain-containing protein 1

  • membrane glycoprotein gp140

CDCP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CDCP1 Q9H5V8 YES1 Homo sapiens P07947
Anti Bait CoIP
21233420
Intra
CDCP1 Q9H5V8 SRC Homo sapiens P12931
Anti Bait CoIP
21725358
Intra
CDCP1 Q9H5V8 SRC Homo sapiens P12931
Anti Bait CoIP
21233420
Intra
CDCP1 Q9H5V8 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
CDCP1 Q9H5V8 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
CDCP1 Q9H5V8 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
CDCP1 Q9H5V8 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
CDCP1 Q9H5V8 SDCBP Homo sapiens O00560
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDCP1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70109 CDCP1 Protein, Human (312a.a, HEK293, His) Q9H5V8-3 (F30-S341) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77891 CDCP1 Protein, Human (HEK293, His) Q9H5V8-1 (F30-L666) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77892 CDCP1 Protein, Human (HEK293, Fc) Q9H5V8-1 (F30-L666) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77893 CDCP1 Protein, Human (Biotinylated, HEK293, His-Avi) Q9H5V8-1 (F30-L666) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700969 CDCP1 Protein, Human (339a.a, HEK293, His) Q9H5V8-1 (F30-R368) ≥ 95%, as determined by reducing SDS-PAGE.

CDCP1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P84802 CDCP1 Antibody (YA4499) FC, ELISA Human
HY-P84802A CDCP1 Antibody (YA4499)(PBS only) IHC-P, ELISA Human

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS02318 CDCP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16620 Cdcp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23055 Cdcp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990361 Anti-CDCP1/CD318 Antibody (38 E11) ≥99.0% Unkown
HY-P992209 Anti-CD318/CDCP1 Antibody (25A11) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDCP1 VGNC VGNC:39018
Macaca mulatta CDCP1 VGNC VGNC:70849
Rattus norvegicus CDCP1 RGD RGD:1305578
Felis catus CDCP1 VGNC VGNC:60671
Bos taurus CDCP1 VGNC VGNC:27089
Mus musculus CDCP1 MGD MGI:2442010
Others CDCP1 NCBI