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Ginisortamab

(Synonyms: UCB6114)
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Based on 1 Customer Validation

Ginisortamab (UCB6114) is a fully human IgG4P anti Gremlin-1 monoclonal antibody, with mean IC50 values of 8.2 nM and 9 nM against human and mouse gremlin-1, respectivly. Ginisortamab inhibits gremlin-1 antagonism of BMP signaling pathways. Ginisortamab has the potential for the research of gastrointestinal (GI) tumors.

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  • Pureté: 99.05%
  • CAS No.: 2390147-17-6
  • Masse moléculaire:147.56 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ginisortamab
  • Experimental Validation Results for Ginisortamab
  • Experimental Validation Results for Ginisortamab
  • Ginisortamab Chemical Structure
    Ginisortamab Chemical Structure
CAS No.: 2390147-17-6
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609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Human Gremlin/GREM1 Protein, His Tag can bind Ginisortamab. The EC50 for this effect is 10.22 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 SH-SY5Y cells labeling GREM1 with Ginisortamab (HY-P99643, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.

  • Ginisortamab Chemical Structure
    1/16
  • Ginisortamab
  • Immobilized Human Gremlin/GREM1 Protein, His Tag can bind Ginisortamab. The EC50 for this effect is 10.22 ng/mL.
  • Flow cytometric analysis of 1X106 SH-SY5Y cells labeling GREM1 with Ginisortamab (HY-P99643, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.