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Cat. No.: HY-185334

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GNE-3565

GNE-3565 is an arylsulfonamide class Na_V1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain.

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CAS No.: 2222537-72-4
Formule: C₂₅H₂₆ClF₄N₅O₂S
Masse moléculaire:572.02

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Please store the product under the recommended conditions in the Certificate of Analysis.

GNE-3565 Chemical Structure

CAS No.: 2222537-72-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
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Description

GNE-3565 is an arylsulfonamide class Na_V1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain^[1].

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In Vitro

GNE-3565 (50 μM; 10 min at 22 °C) binds to the VSD4 domain of the VSD4-NaV1.7-NaVPas chimeric channel in a pose similar to the arylsulfonamide inhibitor GX-936, forming key interactions with the R4 gating charge and subtype-selectivity residues Tyr1537 and Trp1538^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2222537-72-4
Masse moléculaire 572.02
Formule C₂₅H₂₆ClF₄N₅O₂S
SMILES

CN(C)[C@@H](C[C@@H](C1=CC(C(F)(F)F)=CC=C1)CC2)[C@H]2NC3=C(C=C(C(F)=C3)S(NC4=NC=NC=C4)(=O)=O)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kschonsak M, et al. Cryo-EM reveals an unprecedented binding site for Na_V1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife. 2023;12:e84151. Published 2023 Mar 28. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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GNE-3565

Voir tous les produits spécifiques à Isoform Sodium Channel

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

GNE-3565 Related Classifications

HY-185334 Related Classifications