GSK990
GSK990 is an inactive mutant IDH1 inhibitor with no significant inhibitory activity against wild-type or mutant IDH1/IDH2 enzymes. In experiments, GSK990 can serve as an inactive negative control for the IDH1 inhibitor GSK321 (HY-18948). GSK990 is applicable to the research of acute myeloid leukemia.
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- CAS No.: 1816331-64-2
- Formule: C23H23N7O2
- Masse moléculaire:429.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IDH1 |
In Vitro
GSK990 acts as a weak inhibitor of mutant IDH1 enzymes (R132H, R132C, R132G) with IC50 values ranging from 4,495 to 23,255 nM, and shows no inhibitory activity against wild-type IDH1 or any IDH2 variants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1816331-64-2
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Masse moléculaire 429.47
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Formule C23H23N7O2
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SMILES
O=C(NC1=CC=CC(C)=C1)C2=NN(C3=C2CN(CC3)C(C4=CC=CN4)=O)CC5=CNC=N5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK990 Related Classifications
HY-123153 Related Classifications
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