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Cat. No.: HY-121185

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Hexoprenaline

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Hexoprenaline is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline can dilate the bronchi. Hexoprenaline can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline exhibits anti-infection and anti-inflammmation effect. Hexoprenaline can increase placental weight and blood flow. Hexoprenaline can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 96.0%
CAS No.: 3215-70-1
Formule: C₂₂H₃₂N₂O₆
Masse moléculaire:420.50

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Hexoprenaline Chemical Structure

CAS No.: 3215-70-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

β-adrenoceptor

Voir tous les produits spécifiques à Isoform Adrenergic Receptor :

In Vitro

Hexoprenaline (10 nM-1 mM) activates adenylate cyclase in isolated rat gastric mucosal cells^[2].
Hexoprenaline (10-10000 nM) increasingly stimulate 14C-Aminopyrine uptake in isolated rat gastric mucosal cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hexoprenaline (sulfate) (1.5 mg/kg, s.c.) significantly reduces mortality and decreases plasma proinflammatory cytokine concentrations in mice with E. coli O157:H7-induced sepsis^[4].
Hexoprenaline (0.5 mg diet, p.o., daily) increases placental weight and blood flow in blood flow^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with E. coli O157:H7-induced sepsis^[3]
Dosage:

1.5 mg/kg
Administration:

Subcutaneous injection
Result:

Reduced the mortality by 1.98-fold at 4 h and by 1.56-fold at 24 h.
Decreased plasma TNF-α, IL-1β, and IL-6 concentrations.

Chemical Information

CAS No. 3215-70-1
Appearance Solid
Masse moléculaire 420.50
Formule C₂₂H₃₂N₂O₆
Color Light brown to brown
SMILES

OC(CNCCCCCCNCC(O)C1=CC=C(C(O)=C1)O)C2=CC=C(C(O)=C2)O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Schonell M, et al. Bronchodilator effect of hexoprenaline aerosol in bronchial asthma and chronic bronchitis. Med J Aust. 1977 Dec 17;2(25):828-30. [Content Brief]

[2]. Ruoff HJ, et al. Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):175-81. [Content Brief]

[3]. Zabrodskii P F. et al. The Mechanisms of the Cholinergic Anti-Inflammatory Pathway after Acute Intoxication of Organophosphorus Compounds[J]. Biomedical Journal, 2010, 1: 5.

[4]. Zabrodskii P F. et al. The influence of various drugs on mortality of mice and the concentration of proinflammatory cytokines in blood at sepsis caused by E. coli[J]. Acta scientific microbiology, 2018, 1: 11-14.

[5]. Lipshitz J, et al. Effect of long-term administration of beta 2-sympathomimetic drug in the diet-restricted pregnant rat model. Am J Obstet Gynecol. 1986 Feb;154(2):314-7. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références

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Hexoprenaline

Voir tous les produits spécifiques à Isoform Adrenergic Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Hexoprenaline Related Classifications

HY-121185 Related Classifications