HH0043
HH0043 (Compound 10f) is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. HH0043 can be used for the research of cancer.
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- CAS No.: 2922069-42-7
- Formule: C23H24F3N5O
- Masse moléculaire:443.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H358 | IC50 |
322 nM
Compound: 10f; HH0043
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Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as inhibition of cell proliferation incubated for 5 days by celltiter-glo 3D assay
Antiproliferative activity against human NCI-H358 cells harboring KRAS G12C mutant assessed as inhibition of cell proliferation incubated for 5 days by celltiter-glo 3D assay
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[PMID: 38894918] |
Chemical Information
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CAS No. 2922069-42-7
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Masse moléculaire 443.46
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Formule C23H24F3N5O
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SMILES
CC(N(CC1)CCN1C2=CC(C(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=CC=N4)=C4C=N2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HH0043 Related Classifications
HY-161714 Related Classifications
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